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Valentina Onnis   Professor  Senior Scientist or Principal Investigator 
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Valentina Onnis published an article in April 2019.
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Top co-authors See all
Claudiu T. Supuran

1753 shared publications

E Department of Neurofarba , University of Florence , Sesto Fiorentino (Firenze) , Italy

Valentina Onnis

141 shared publications

A Department of Life and Environmental Sciences - Unit of Pharmaceutical, Pharmacological and Nutraceutical Sciences , University of Cagliari , Cagliari , Italy

Cenzo Congiu

97 shared publications

Department of Life and Environmental Sciences, Unit of Pharmaceutical, Pharmacological and Nutraceutical Sciences, University of Cagliari, via Ospedale 72, Cagliari, I-09124, Italy

Jan Balzarini

78 shared publications

KU Leuven—University of Leuven, Department of Microbiology and Immunology, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, Leuven B-3000, Belgium;(S.L.);(J.B.)

Sandra Liekens

33 shared publications

KU Leuven—University of Leuven, Department of Microbiology and Immunology, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, Leuven B-3000, Belgium;(S.L.);(J.B.)

124
Publications
15
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264
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Distribution of Articles published per year 
(1991 - 2019)
Total number of journals
published in
 
18
 
Publications See all
Article 0 Reads 0 Citations Indole derivatives as multifunctional drugs: Synthesis and evaluation of antioxidant, photoprotective and antiproliferat... Monica Demurtas, Anna Baldisserotto, Ilaria Lampronti, David... Published: 01 April 2019
Bioorganic Chemistry, doi: 10.1016/j.bioorg.2019.02.007
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Article 0 Reads 0 Citations Benzylamides and piperazinoarylamides of ibuprofen as fatty acid amide hydrolase inhibitors Alessandro Deplano, Mariateresa Cipriano, Federica Moraca, E... Published: 27 January 2019
Journal of Enzyme Inhibition and Medicinal Chemistry, doi: 10.1080/14756366.2018.1532418
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Article 0 Reads 0 Citations Benzylamides and piperazinoarylamides of ibuprofen as fatty acid amide hydrolase inhibitors Alessandro Deplano, Mariateresa Cipriano, Federica Moraca, E... Published: 27 January 2019
Journal of Enzyme Inhibition and Medicinal Chemistry,
PubMed View at PubMed ABS Show/hide abstract
Fatty Acid Amide Hydrolase (FAAH) is a serine hydrolase that plays a key role in controlling endogenous levels of endocannabinoids. FAAH inhibition is considered a powerful approach to enhance the endocannabinoid signalling, and therefore it has been largely studied as a potential target for the treatment of neurological disorders such as anxiety or depression, or of inflammatory processes. We present two novel series of amide derivatives of ibuprofen designed as analogues of our reference FAAH inhibitor Ibu-AM5 to further explore its structure-activity relationships. In the new amides, the 2-methylpyridine moiety of Ibu-AM5 was substituted by benzylamino and piperazinoaryl moieties. The obtained benzylamides and piperazinoarylamides showed FAAH inhibition ranging from the low to high micromolar potency. The binding of the new amides in the active site of FAAH, estimated using the induced fit protocol, indicated arylpiperazinoamides binding the ACB channel and the cytosolic port, and benzylamides binding the ACB channel.
Article 0 Reads 1 Citation Benzofuran hydrazones as potential scaffold in the development of multifunctional drugs: Synthesis and evaluation of ant... Anna Baldisserotto, Monica Demurtas, Ilaria Lampronti, David... Published: 01 August 2018
European Journal of Medicinal Chemistry, doi: 10.1016/j.ejmech.2018.07.001
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Article 0 Reads 0 Citations Synthesis and biological evaluation of novel pyrazoline-based aromatic sulfamates with potent carbonic anhydrase isoform... Alessio Nocentini, Davide Moi, Gianfranco Balboni, Severo Sa... Published: 01 April 2018
Bioorganic Chemistry, doi: 10.1016/j.bioorg.2018.02.021
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Article 0 Reads 3 Citations Discovery of thiazolin-4-one-based aromatic sulfamates as a new class of carbonic anhydrase isoforms I, II, IV, and IX i... Alessio Nocentini, Davide Moi, Gianfranco Balboni, Valentina... Published: 01 April 2018
Bioorganic Chemistry, doi: 10.1016/j.bioorg.2018.01.023
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