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Tanja Soldatovic   Professor  Institute, Department or Faculty Head 
Affiliations
Department of Chemical-Technological Sciences, State University of Novi Pazar, Vuka Karadžića bb, 36300 Novi Pazar, Serbia
Timeline See timeline
Tanja Soldatovic published an article in January 2019.
Research Keywords & Expertise See all
0 Amino Acids
0 Bioinorganic Chemistry
0 Copper
0 DNA
0 EPR
0 GMP
Top co-authors
Enisa Selimovic

6 shared publications

State University of Novi Pazar

Braho Licina

2 shared publications

State University of Novi Pazar

7
Publications
65
Reads
12
Downloads
4
Citations
Publication Record
Distribution of Articles published per year 
(2016 - 2019)
Total number of journals
published in
 
4
 
Publications See all
Article 0 Reads 0 Citations Interactions of zinc(II) complexes with 5′-GMP and their cytotoxic activity Tanja V. Soldatović, Enisa Selimović, Biljana Šmit, Darko Aš... Published: 17 January 2019
Journal of Coordination Chemistry, doi: 10.1080/00958972.2019.1569229
DOI See at publisher website
Article 1 Read 1 Citation Impact of Chloride Concentration on Ligand Substitution Reactions of Zinc(II) Complexes with Biologically Relevant Nitro... Enisa Selimović, Tanja Soldatovic Published: 01 October 2018
Progress in Reaction Kinetics and Mechanism, doi: 10.3184/146867818x15319903829164
DOI See at publisher website
Article 9 Reads 2 Citations Substitution behavior of square-planar and square-pyramidal Cu(II) complexes with bio-relevant nucleophiles Enisa Selimović, Andrei V. Komolkin, Andrei V. Egorov, Tanja... Published: 03 April 2018
Journal of Coordination Chemistry, doi: 10.1080/00958972.2018.1456656
DOI See at publisher website
Article 1 Read 3 Citations Kinetic Studies of the Reactions between Dichlorido(1,2-Diaminoethane)Zinc(II) and Biologically Relevant Nucleophiles in... Tanja Soldatovic, Enisa Selimović Published: 01 March 2018
Progress in Reaction Kinetics and Mechanism, doi: 10.3184/146867818x15066862094897
DOI See at publisher website
CONFERENCE-ARTICLE 32 Reads 0 Citations <strong>Interaction of Zinc(II) Complexes with Relevant Nitrogen Nucleophiles under Physiological Conditions</strong> Tanja Soldatovic, Enisa Selimovic Published: 01 November 2017
Proceedings of 3rd International Electronic Conference on Medicinal Chemistry, doi: 10.3390/ecmc-3-04638
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In recent years, the field of medicinal inorganic chemistry has received considerable attention for the design of anticancer agents. Zinc(II) ion plays an important role in bioinorganic processes because of the potential formation of coordination compounds in which zinc(II) ion can readily accommodate four-, five-, or six molecules. The advantage of zinc-based anticancer drugs could be their selectivity toward specific cellular targets thanks to specific coordination ability and kinetic properties  (Bertini I., et al., Biological Inorganic Chemistry. Structure and Reactivity, University Science Books: Sausalito, CA, 2007; Roat-Malone R.M. (Ed.), Bioinorganic Chemistry: A Short Course, John Wiley & Sons, Inc., Hoboken, NJ, 2002). 

The mole-ratio method was used for determining metal-ligand stoichiometry between [ZnCl2(en)] (where en=  1,2-diaminoethane or ethylenediamine) and imidazole at pH 7.2 in the presence of different chloride concentrations. The results indicated step-wise formation of 1:1 and 1:2 complexes in the presence of 0.010 M NaCl and 1:1 complexes in the presence of 0.001 M NaCl. Those results are correlated with additional coordination of chlorides in the first coordination sphere and with changes in coordination geometry. In the presence of 0.001 M NaCl, five-coordinate complex anion [ZnCl3(en)]- is formed initially, and then substitution reaction with imidazole occurred. In the presence of 0.010 M NaCl the octahedral complex anion [ZnCl4(en)]2- formed.

The kinetics of ligand substitution reactions between complex and relevant nitrogen nucleophiles such as imidazole, 1,2,3-triazole and L-histidine were investigated at pH 7.2 as a function of nucleophile concentration in the presence of 0.001 M and 0.010 M NaCl. The reactions were followed under pseudo-first-order conditions by UV-vis spectrophotometry. The substitution reactions included two steps of consecutive displacement of chlorido ligands and changes in coordination geometry of [ZnCl2(en)] complex. Results are discussed in terms of mechanisms of interactions between potential antitumor zinc-based drugs and biomolecules.

CONFERENCE-ARTICLE 9 Reads 0 Citations <strong>Interaction of Zinc(II) and Copper(II) Terpyridine Complexes with Biomolecules</strong> Enisa Selimovic, Tanja Soldatovic Published: 01 November 2016
Proceedings of 2nd International Electronic Conference on Medicinal Chemistry, doi: 10.3390/ecmc-2-A001
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Transition metal ions exhibit a unique role in diverse biological activities of proteins by acting as cofactors. In particular, zinc and copper ions modulate enzymes activities as well as many catalytic and oxidative/reductive processes. The kinetics and mechanism of the substitution reactions of dichloro [ZnCl2(terpy)] and [CuCl2(terpy)]  (terpy = 2,2′:6′,2′′-terpyridine) with biologically relevant ligands have been studied as a function of nucleophile concentrations at pH 7.38, under pseudo-first-order condition by UV-Vis spectrophotometric techniques. The interactions of Cu(II) and Zn(II) complexes with tripeptide glutathione (GSH) were investigated under pseudo-first-order conditions with respect to the complex concentration. For the substitution process of Zn(II) complex with glutathione (GSH), pre-equilibrium and chelate formation have been noted. The [CuCl2(terpy)] is more reactive than [ZnCl2(terpy)] complex and the second-order rate constants for the first step follow the order of reactivity: GSH > DL-Asp > L -Met > 5’-GMP ~ 5’-IMP for Cu(II)  complex,  while for Zn(II) the order of reactivity is: DL-Asp >  L -Met > GSH ~  5’-GMP > 5’-IMP. The results are discussed in terms of mechanisms of interactions between metalloproteins and biomolecules.

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