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Nagatoshi Nishiwaki     Senior Scientist or Principal Investigator 
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Nagatoshi Nishiwaki published an article in January 2019.
Top co-authors
Haruyasu Asahara

52 shared publications

Division of Applied Chemistry, Graduate School of Engineering, Osaka University, Yamadaoka 2-1, Suita, Osaka 565-0871, Japan

Takahiro Hosokawa

4 shared publications

Sch. Environ. Sci. Eng., Kochi Univ. Technol., Kami, Kochi 782, Japan

Masato Ohsumi

1 shared publications

Kochi National College of Technology, Nankoku, Kochi 783-8508, Japan

83
Publications
31
Reads
15
Downloads
88
Citations
Publication Record
Distribution of Articles published per year 
(1989 - 2019)
Total number of journals
published in
 
24
 
Publications See all
Article 0 Reads 0 Citations Metal-Free O-Selective Direct Acylation of Amino Alcohols via Pseudo-Intramolecular Process Soichi Yokoyama, Hiroshi Shibauchi, Haruyasu Asahara, Nagato... Published: 04 January 2019
European Journal of Organic Chemistry, doi: 10.1002/ejoc.201801589
DOI See at publisher website
Article 0 Reads 0 Citations Fluorescence Behavior of Bis(cyanostyryl)pyrrole Derivatives Depending on the Substituent Position of Cyano Groups in So... Soichi Yokoyama, Nagatoshi Nishiwaki Published: 02 January 2019
The Journal of Organic Chemistry, doi: 10.1021/acs.joc.8b02517
DOI See at publisher website
Article 0 Reads 0 Citations Alkynylation and Cyanation of Alkenes Using Diverse Properties of a Nitro Group Haruyasu Asahara, Ayano Sofue, Yasuyuki Kuroda, Nagatoshi Ni... Published: 25 October 2018
The Journal of Organic Chemistry, doi: 10.1021/acs.joc.8b01865
DOI See at publisher website
Article 0 Reads 1 Citation Selective Synthesis of (Benzyl)biphenyls by Successive Suzuki–Miyaura Coupling of Phenylboronic Acids with 4-Bromobenzyl... Masato Ohsumi, Nagatoshi Nishiwaki Published: 09 November 2017
ACS Omega, doi: 10.1021/acsomega.7b01450
DOI See at publisher website
Article 0 Reads 0 Citations Direct Aziridination of Nitroalkenes Affording N -Alkyl- C -nitroaziridines and the Subsequent Lewis Acid Mediated Isome... Feiyue Hao, Haruyasu Asahara, Nagatoshi Nishiwaki Published: 21 September 2017
Organic Letters, doi: 10.1021/acs.orglett.7b02724
DOI See at publisher website PubMed View at PubMed
Article 0 Reads 0 Citations Synthesis of Functionalized 3-Cyanoisoxazoles Using a Dianionic Reagent Kento Iwai, Haruyasu Asahara, Nagatoshi Nishiwaki Published: 09 May 2017
The Journal of Organic Chemistry, doi: 10.1021/acs.joc.7b00811
DOI See at publisher website PubMed View at PubMed
Conference papers
CONFERENCE-ARTICLE 31 Reads 0 Citations An introduction to the synthesis of nitroanilines and nitropyridines via three component ring transformation Song Thi Le, Nagatoshi Nishiwaki Published: 31 October 2018
doi: 10.3390/ecmc-4-05616
DOI See at publisher website ABS Show/hide abstract

Nitro compounds show great importance in chemistry, biology and material sciences. Among them, nitropyridines and nitroanilines are widely used as useful intermediates for synthesis of biologically active compounds of pharmaceutical and agrochemical importance. Hence, we reported a powerful method for synthesis of various kinds of nitro compounds by using a three component ring transformation (TCRT) of dinitropyridone 1 with ketones in the presence of less nucleophilic ammonium acetate (NH4OAc) as nitrogen source.

When pyridone 1 was reacted with aromatic ketone in the presence of ammonium acetate, 6-arylated 3-nitropyriines 2 were formed besides diazabicyclo compounds 3. This method was also applicable to cycloalkanones and α,β-unsaturated ketones to afford cycloalka[b]pyridines 4 and 6-alkynylated/alkenylated pyridines 5, respectively. It was found to be possible to use aldehydes as the substrate, what led to 3,5-disubstituted pyridines 6.

On the other hand, when aliphatic ketones were employed as the substrate, two kinds of ring transformation proceeded. Namely, 2,6-disubstituted 4-nitroanilines 8 were formed in addition to nitropyridines 7. This protocol was successful applied to synthesis of N,N,2,6-tetrasubstituted nitroanilines 9 upon treatment of dinitropyridone 1 with ketone and amine in the presence of acetic acid.

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