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Eugénia Pinto   Professor  University Lecturer 
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Eugénia Pinto published an article in February 2019.
Top co-authors See all
Madalena M.M. Pinto

257 shared publications

LQOF—Laboratório de Química Orgânica e Farmacêutica, Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal

Lígia R. Salgueiro

140 shared publications

CNC.IBILI, Faculty of Pharmacy, University of Coimbra, Azinhaga de S. Comba, 3000-354 Coimbra, Portugal;(M.-J.G.);(C.C.);(L.S.)

Paulo J.G. Coutinho

134 shared publications

Centro de Física da Universidade do Minho (CFUM), Campus de Gualtar, 4710-057 Braga, Portugal

Emília Sousa

112 shared publications

Laboratory of Organic and Pharmaceutical Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal

Maria-João R. P. Queiroz

112 shared publications

Centro de Química da Universidade do Minho (CQUM), Campus de Gualtar, 4710-057 Braga, Portugal.

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360
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Publication Record
Distribution of Articles published per year 
(2001 - 2019)
Total number of journals
published in
 
33
 
Publications See all
Article 0 Reads 0 Citations Aspergillus species collected from environmental air samples in Portugal—molecular identification, antifungal susceptibi... Carolina Monteiro, Dolores Pinheiro, Marta Maia, Miguel A. F... Published: 27 February 2019
Journal of Applied Microbiology, doi: 10.1111/jam.14217
DOI See at publisher website
Article 3 Reads 2 Citations Lichen Xanthones as Models for New Antifungal Agents Diana I. S. P. Resende, Patrícia Pereira-Terra, Ângela S. In... Published: 12 October 2018
Molecules, doi: 10.3390/molecules23102617
DOI See at publisher website PubMed View at PubMed ABS Show/hide abstract
Due to the emergence of multidrug-resistant pathogenic microorganisms, the search for new antimicrobial compounds plays an important role in current medicinal chemistry research. Inspired by lichen antimicrobial xanthones, a series of novel chlorinated xanthones was prepared using five chlorination methods (Methods A–E) to obtain different patterns of substitution in the xanthone scaffold. All the synthesized compounds were evaluated for their antimicrobial activity. Among them, 3-chloro-4,6-dimethoxy-1-methyl-9H-xanthen-9-one 15 showed promising antibacterial activity against E. faecalis (ATCC 29212 and 29213) and S. aureus ATCC 29213. 2,7-Dichloro-3,4,6-trimethoxy-1-methyl-9H-xanthen-9-one 18 revealed a potent fungistatic and fungicidal activity against dermatophytes clinical strains (T. rubrum, M. canis, and E. floccosum (MIC = 4–8 µg/mL)). Moreover, when evaluated for its synergistic effect for T. rubrum, compound 18 exhibited synergy with fluconazole (ΣFIC = 0.289). These results disclosed new hit xanthones for both antibacterial and antifungal activity.
Article 0 Reads 0 Citations Cleaner production of antimicrobial and anti-UV cotton materials through dyeing with eucalyptus leaves extract Márcia Gomes Da Silva, Maria Angélica S. D. De Barros, Rafae... Published: 01 October 2018
Journal of Cleaner Production, doi: 10.1016/j.jclepro.2018.07.221
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Article 0 Reads 0 Citations Aspergillus Species and Antifungals Susceptibility in Clinical Setting in the North of Portugal: Cryptic Species and Eme... Eugénia Pinto, Carolina Monteiro, Marta Maia, Miguel A Faria... Published: 23 July 2018
Frontiers in Microbiology,
PubMed View at PubMed ABS Show/hide abstract
Aspergillus spp. are agents of a broad-spectrum of diseases among humans. Their growing resistance to azoles, the cornerstone in the management of human aspergillosis, is a worrisome problem around the world. Considering lack of data from Portugal on this topic, particularly from the northern region, a retrospective surveillance study was planned to assess frequency of cryptic Aspergillus species and azoles resistance. A total of 227 clinical isolates, mainly from the respiratory tract (92.1%), collected from three hospitals serving a population of about three million people, were studied for their epidemiology and antifungal susceptibility patterns determined by the E.DEF.9.3 protocol of EUCAST. Employing molecular methods, seven Aspergillus complexes were identified; Aspergillus fumigatus sensu stricto was the most frequent isolate (86.7%). A 7.5% prevalence of cryptic species was found; A. welwitschiae (A. niger complex-3.1%) and A. lentulus (A. fumigatus complex-2.2%) were the most frequent. Amongst cryptic species, it was found a percentage of resistance to voriconazole, posaconazole and isavuconazole of 47.1, 82.4, and 100%, respectively. Five A. fumigatus sensu stricto showed pan-azole resistance. Sequencing their cyp51A gene revealed the presence of one isolate with TR46/Y121F/T289A mutation and two isolates with TR34/L98H mutation. This study emphasizes the need to identify strains to the species level and to evaluate their antifungal susceptibility in all human originated Aspergillus spp. isolates, particularly those from invasive aspergillosis.
Article 0 Reads 1 Citation Aspergillus Species and Antifungals Susceptibility in Clinical Setting in the North of Portugal: Cryptic Species and Eme... Eugénia Pinto, Carolina Monteiro, Marta Maia, Miguel A. Fari... Published: 23 July 2018
Frontiers in Microbiology, doi: 10.3389/fmicb.2018.01656
DOI See at publisher website ABS Show/hide abstract
Aspergillus spp. are agents of a broad-spectrum of diseases among humans. Their growing resistance to azoles, the cornerstone in the management of human aspergillosis, is a worrisome problem around the world. Considering lack of data from Portugal on this topic, particularly from the northern region, a retrospective surveillance study was planned to assess frequency of cryptic Aspergillus species and azoles resistance. A total of 227 clinical isolates, mainly from the respiratory tract (92.1%), collected from three hospitals serving a population of about three million people, were studied for their epidemiology and antifungal susceptibility patterns determined by the E.DEF.9.3 protocol of EUCAST. Employing molecular methods, seven Aspergillus complexes were identified; Aspergillus fumigatus sensu stricto was the most frequent isolate (86.7%). A 7.5% prevalence of cryptic species was found; A. welwitschiae (A. niger complex-3.1%) and A. lentulus (A. fumigatus complex-2.2%) were the most frequent. Amongst cryptic species, it was found a percentage of resistance to voriconazole, posaconazole and isavuconazole of 47.1, 82.4, and 100%, respectively. Five A. fumigatus sensu stricto showed pan-azole resistance. Sequencing their cyp51A gene revealed the presence of one isolate with TR46/Y121F/T289A mutation and two isolates with TR34/L98H mutation. This study emphasizes the need to identify strains to the species level and to evaluate their antifungal susceptibility in all human originated Aspergillus spp. isolates, particularly those from invasive aspergillosis.
Article 0 Reads 2 Citations First description of clinical Aspergillus fumigatus cyp51A TR 46 /Y121F/T289A mutant in Portugal Carolina Monteiro, Miguel A. Faria, Dolores Pinheiro, Catari... Published: 01 June 2018
Journal of Global Antimicrobial Resistance, doi: 10.1016/j.jgar.2018.04.016
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