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Aiva Plotniece     Senior Scientist or Principal Investigator 
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Aiva Plotniece published an article in November 2018.
Top co-authors See all
Marina Petrova

73 shared publications

Department of Medicinal Chemistry; Latvian Institute of Organic Synthesis; Aizkraukles 21 LV-1006 Riga Latvia

G. Duburs

70 shared publications

Latvian Institute of Organic Synthesis, Aizkraukles str. 21, Riga, LV-1006, Latvia

Velta Ose

30 shared publications

Latvian Biomedical Research and Study Centre, Ratsupites St, Riga, LV-1067, Latvia

Brigita Vīgante

28 shared publications

Latvian Institute of Organic Synthesis, Aizkraukles iela 21, LV-1006 Riga, Latvia

Karlis Pajuste

22 shared publications

Latvian Institute of Organic Synthesis, Aizkraukles iela 21, LV-1006 Riga, Latvia

37
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52
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Publication Record
Distribution of Articles published per year 
(1997 - 2018)
Total number of journals
published in
 
25
 
Publications See all
CONFERENCE-ARTICLE 17 Reads 0 Citations Pleiotropic focused anticancer approach by dihydropyridines, dihydropyrimidines and heteroaromatic compounds Gunars Duburs, Brigita Vigante, Egils Bisenieks, Aivars Krau... Published: 14 November 2018
Proceedings of 4th International Electronic Conference on Medicinal Chemistry, doi: 10.3390/ecmc-4-05778
DOI See at publisher website ABS Show/hide abstract

Complex, focused anticancer therapy approach has been developed in the Latvian Institute of Organic Synthesis by making use of privileged partially hydrogenated nitrogen-containing heterocycles, namely dihydropyridines, dihydropyrimidines, their oxidized heteroaromatic derivatives. Topics of research include:

1. Conventional approach by chemotherapy and synergism of anticancer drugs [1];

2. Inhibition of multidrug resistance by inhibition of drug efflux pumps [2];

3. Mitigation of cancer risk factors – e.g., hepatitis B virus chemotherapy for prevention of chronic liver diseases, because chronic hepatitis, in up to 40% of cases, progresses to cyrrhosis and further to hepatocellular carcinoma [3];

4. Improvement of efficacy of cancer radiotherapy by use of radioprotectors to prevent damage of normal tissues. So, radioprotector diethone (dietone) for skin protection was discovered, elaborated, and developed as ointment. Compounds for protection of eyes, mucous tissues, salivary glands etc have been synthesized. Toxicity of dietone and novel radioprotectors is very low;

5.Amphiphilic compounds have been synthesized, nanoparticles for anticancer drug and gene delivery have been created, pleiotropic properties have been checked, inclusion of magnetic particles for targeted transport performed [4].

Acknowledgements

The research was partially supported by the Latvian State Program Biomedicine.

References

1.Bisenieks E., Duburs G. et al., Pharmaceutical combination of 5-fluorouracil and derivatives of 1,4-dihydropyridine. US 8492413B2, 2013.

2.Krauze A., Grinberga S. et al., Thieno[2,3-b]pyridines – a new class of multidrug resistance (MDR) modulators. Bioorg.Med.Chem. 2014, 22 (21), 5860-5870.

3.Sipola A., Dubova U., et al., Synthesis and evaluation of 1,4-dihydropyrimidine derivatives – hepatitis B virus capsid self-assembly inhibitors. EFMC International Symposium on Medicinal Chemistry. Ljubljana, Slovenia, 2018, P176.

4.Pajuste K. et al., Gene delivery agents possessing antiradical activity: Self-assembling cationic amphiphilic 1,4-dihydropyridine derivatives. New J.Chem. 2013, 37 (10), 3062-3075.

Article 0 Reads 0 Citations Determination of Hormone Antagonists in Waste-Water Samples by Micellar Electrokinetic Chromatography Martins Rucins, Daniel Baron, Aiva Plotniece, Jan Petr Published: 22 October 2018
Chromatographia, doi: 10.1007/s10337-018-3631-0
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Article 0 Reads 0 Citations Synthesis and Comparative Evaluation of Novel Cationic Amphiphile C12-Man-Q as an Efficient DNA Delivery Agent In Vitro Gunita Apsite, Irena Timofejeva, Aleksandra Vezane, Brigita ... Published: 26 June 2018
Molecules, doi: 10.3390/molecules23071540
DOI See at publisher website ABS Show/hide abstract
New amphiphilic 1,4-DHP derivative C12-Man-Q with remoted cationic moieties at positions 2 and 6 was synthesised to study DNA delivery activity. The results were compared with data obtained for cationic 1,4-DHP derivative D19, which is known to be the most efficient one among the previously tested 1,4-DHP amphiphiles. We analysed the effects of C12-Man-Q concentration, complexation media, and complex/cell contact time on the gene delivery effectiveness and cell viability. Transmission electron microscopy data confirms that lipoplexes formed by the compound C12-Man-Q were quite uniform, vesicular-like structures with sizes of about 50 nm, and lipoplexes produced by compound D19 were of irregular shapes, varied in size in the range of 25–80 nm. Additionally, confocal microscopy results revealed that both amphiphiles effectively delivered green fluorescent protein expression plasmid into BHK-21 cells and produced a fluorescent signal with satisfactory efficiency, although compound C12-Man-Q was more cytotoxic to the BHK-21 cells with an increase of concentration. It can be concluded that optimal conditions for C12-Man-Q lipoplexes delivery in BHK-21 cells were the serum free media without 0.15 M NaCl, at an N/P ratio of 0.9. Compound D19 showed higher transfection efficiency to transfect BHK-21 and Cos-7 cell lines, when transfecting active proliferating cells. Although D19 was not able to transfect all studied cell lines we propose that it could be cell type specific. The compound C12-Man-Q showed modest delivery activity in all used cell lines, and higher activity was obtained in the case of H2-35 and B16 cells. The transfection efficiency in cell lines MCF-7, HeLa, and Huh-7 appears to be comparable to the reference compound D19 and minimal in the HepG2 cell line.
Article 0 Reads 0 Citations Bactericidal and immunomodulatory properties of magnetic nanoparticles functionalized by 1,4-dihydropyridines Katarzyna Niemirowicz-Laskowska, Katarzyna Głuszek, Ewelina ... Published: 01 June 2018
International Journal of Nanomedicine, doi: 10.2147/ijn.s157564
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Bactericidal and immunomodulatory properties of magnetic nanoparticles functionalized by 1,4-dihydropyridines Katarzyna Niemirowicz-Laskowska,1 Katarzyna GÅ
Article 0 Reads 0 Citations Synthesis of fluorinated 2,6-heptanediones and 2-oxa-6- azabicyclo[2.2.2]octanes from 1,4-dihydropyridines Nadiia V. Pikun, Natalya P. Kolesnyk, Eduard B. Rusanov, Aiv... Published: 01 June 2018
Tetrahedron, doi: 10.1016/j.tet.2018.04.075
DOI See at publisher website
Article 0 Reads 0 Citations Study of interactions of mononucleotides with 1,4-dihydropyridine vesicles using NMR and ITC techniques Ruslan Muhamadejev, Marina Petrova, Rufus Smits, Aiva Plotni... Published: 01 January 2018
New Journal of Chemistry, doi: 10.1039/c8nj00160j
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