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Diana Resende   Dr.  Research or Laboratory Scientist 
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Diana Resende published an article in March 2019.
Top co-authors See all
Artur M.S. Silva

801 shared publications

University of AveiroChemistry Campus Universitário de Santiago 3810-193 Aveiro PORTUGAL

Madalena M.M. Pinto

257 shared publications

LQOF—Laboratório de Química Orgânica e Farmacêutica, Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal

Anake Kijjoa

153 shared publications

CIIMAR - Interdisciplinary Centre of Marine and Environmental Research, University of Porto, Terminal de Cruzeiros de Leixões, Avenida General Norton de Matos s/n, 4450-208 Matosinhos, Portugal; ICBAS - Abel Salazar Biomedical Sciences Institute, University of Porto, Rua Jorge de Viterbo Ferreira, 228, 4050-313 Porto, Portugal

Emília Sousa

112 shared publications

Laboratory of Organic and Pharmaceutical Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal

M. Helena Vasconcelos

110 shared publications

Instituto de Investigação e Inovação em Saúde (i3S), University of Porto, 4200-135 Porto, Portugal;(R.F.);(C.P.R.X.);(M.H.V.)

12
Publications
9
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1
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36
Citations
Publication Record
Distribution of Articles published per year 
(2009 - 2019)
Total number of journals
published in
 
9
 
Publications See all
Article 1 Read 0 Citations Antithrombotics from the Sea: Polysaccharides and Beyond Francisca Carvalhal, Ricardo R. Cristelo, Diana I. S. P. Res... Published: 16 March 2019
Marine Drugs, doi: 10.3390/md17030170
DOI See at publisher website ABS Show/hide abstract
Marine organisms exhibit some advantages as a renewable source of potential drugs, far beyond chemotherapics. Particularly, the number of marine natural products with antithrombotic activity has increased in the last few years, and reports show a wide diversity in scaffolds, beyond the polysaccharide framework. While there are several reviews highlighting the anticoagulant and antithrombotic activities of marine-derived sulfated polysaccharides, reports including other molecules are sparse. Therefore, the present paper provides an update of the recent progress in marine-derived sulfated polysaccharides and quotes other scaffolds that are being considered for investigation due to their antithrombotic effect.
Article 0 Reads 0 Citations Synthesis of New Proteomimetic Quinazolinone Alkaloids and Evaluation of Their Neuroprotective and Antitumor Effects Solida Long, Diana I. S. P. Resende, Anake Kijjoa, Artur M. ... Published: 01 February 2019
Molecules, doi: 10.3390/molecules24030534
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New quinazolinone derivatives of the marine-derived alkaloids fiscalin B (3) and fumiquinazoline G (1), with neuroprotective and antitumor effects, were synthesized. Eleven quinazolinone-containing indole alkaloids were synthesized, proceeding the anti analogs via a one-pot method, and the syn analogs by the Mazurkiewicz-Ganesan approach. The neuroprotection capacity of these compounds on the rotenone-damage human neuroblastoma cell SH-SY5y was evaluated using the MTT assay. Compounds 1, 3, 5, and 7 showed more than 25% protection. The antitumor activity was investigated using the sulforhodamine B assay and some compounds were tested on the non-malignant MCF-12A cells. Fumiquinazoline G (1) was the most potent compound, with GI50 values lower than 20 µM. Compounds 5, 7, and 11 were more active in all tumor cell lines when compared to their enantiomers. Compounds 5, 7, 10, and 11 had very little effect in the viability of the non-malignant cells. Differences between enantiomeric pairs were also noted as being essential for these activities the S-configuration at C-4. These results reinforce the previously described activities of the fiscalin B (3) as substance P inhibitor and fumiquinazoline G (1) as antitumor agent showing potential as lead compounds for the development of drugs for treatment of neurodegenerative disorders and cancer, respectively.
Article 0 Reads 2 Citations Chemistry of the fumiquinazolines and structurally related alkaloids Diana I. S. P. Resende, Papichaya Boonpothong, Emília Sousa,... Published: 01 January 2019
Natural Product Reports, doi: 10.1039/c8np00043c
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Article 3 Reads 2 Citations Lichen Xanthones as Models for New Antifungal Agents Diana I. S. P. Resende, Patrícia Pereira-Terra, Ângela S. In... Published: 12 October 2018
Molecules, doi: 10.3390/molecules23102617
DOI See at publisher website PubMed View at PubMed ABS Show/hide abstract
Due to the emergence of multidrug-resistant pathogenic microorganisms, the search for new antimicrobial compounds plays an important role in current medicinal chemistry research. Inspired by lichen antimicrobial xanthones, a series of novel chlorinated xanthones was prepared using five chlorination methods (Methods A–E) to obtain different patterns of substitution in the xanthone scaffold. All the synthesized compounds were evaluated for their antimicrobial activity. Among them, 3-chloro-4,6-dimethoxy-1-methyl-9H-xanthen-9-one 15 showed promising antibacterial activity against E. faecalis (ATCC 29212 and 29213) and S. aureus ATCC 29213. 2,7-Dichloro-3,4,6-trimethoxy-1-methyl-9H-xanthen-9-one 18 revealed a potent fungistatic and fungicidal activity against dermatophytes clinical strains (T. rubrum, M. canis, and E. floccosum (MIC = 4–8 µg/mL)). Moreover, when evaluated for its synergistic effect for T. rubrum, compound 18 exhibited synergy with fluconazole (ΣFIC = 0.289). These results disclosed new hit xanthones for both antibacterial and antifungal activity.
Article 1 Read 2 Citations Antitumor Activity of Quinazolinone Alkaloids Inspired by Marine Natural Products Solida Long, Diana I. S. P. Resende, Anake Kijjoa, Artur M. ... Published: 31 July 2018
Marine Drugs, doi: 10.3390/md16080261
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Many fungal quinazolinone metabolites, which contain the methyl-indole pyrazino [1,2-b]quinazoline-3,6-dione core, have been found to possess promising antitumor activity. The purpose of this work was to synthesize the enantiomeric pairs of two members of this quinazolinone family, to explore their potential as antitumor and their ability to revert multidrug resistance. The marine natural product fiscalin B (4c), and antienantiomers (4b, 5b, and 5c) were synthesized via a one-pot approach, while the syn enantiomers (4a, 4d, 5a, and 5d) were synthetized by a multi-step procedure. These strategies used anthranilic acid (i), chiral N-protected α-amino acids (ii), and tryptophan methyl esters (iii) to form the core ring of pyrazino[2,1-b]quinazoline-3,6-dione scaffold. Four enantiomeric pairs, with different enantiomeric purities, were obtained with overall yields ranging from 7 to 40%. Compounds 4a–d and 5a–d were evaluated for their growth inhibitory effect against two tumor cell lines. Differences between enantiomeric pairs were noted and 5a–d displayed GI50 values ranging from 31 to 52 μM, which are lower than those of 4a–d. Nevertheless, no effect on P-glycoprotein (P-gp) modulation was observed for all compounds. This study disclosed new data for fiscalin B (4c), as well as for its analogues for a future development of novel anticancer drug leads.
Article 0 Reads 1 Citation Do cinnamylideneacetophenones have antioxidant properties and a protective effect toward the oxidation of phosphatidylch... Eduarda M.P. Silva, Tânia Melo, Bebiana C. Sousa, Diana I.S.... Published: 01 October 2016
European Journal of Medicinal Chemistry, doi: 10.1016/j.ejmech.2016.05.040
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