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Barbara A. Byrne  - - - 
Top co-authors See all
Lisa A. Tell

106 shared publications

Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California at Davis, One Shields Avenue, Davis, CA 95616, USA

Luisa W. Cheng

46 shared publications

Foodborne Toxin Detection and Prevention Research Unit, Western Regional Research Center, USDA-ARS, 800 Buchanan St., Albany, CA 94710, USA

Kirkwood M. Land

37 shared publications

Department of Biological Sciences, University of the Pacific, 3601 Pacific Avenue, Stockton, CA 95211, USA

Melissa Miller

35 shared publications

California Department of Fish and Wildlife, Office of Spill Prevention and Response, Marine Wildlife Veterinary Care & Research Center, 151 McAllister Way, Santa Cruz, California 95060, USA

Woutrina A Miller

7 shared publications

Pathology, Microbiology & Immunology Department, School of Veterinary Medicine, University of California, Davis, CA, 95616, USA

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Publication Record
Distribution of Articles published per year 
(2006 - 2019)
Total number of journals
published in
 
9
 
Publications See all
Article 0 Reads 0 Citations High Efficiency Drug Repurposing Design for New Antifungal Agents Jong H. Kim, Kathleen L. Chan, Luisa W. Cheng, Lisa A. Tell,... Published: 17 April 2019
Methods and Protocols, doi: 10.3390/mps2020031
DOI See at publisher website ABS Show/hide abstract
Current antifungal interventions have often limited efficiency in treating fungal pathogens, particularly those resistant to commercial drugs or fungicides. Antifungal drug repurposing is an alternative intervention strategy, whereby new utility of various marketed, non-antifungal drugs could be repositioned as novel antifungal agents. In this study, we investigated ‚Äúchemosensitization‚ÄĚ as a method to improve the efficiency of antifungal drug repurposing, wherein combined application of a second compound (viz., chemosensitizer) with a conventional, non-antifungal drug could greatly enhance the antifungal activity of the co-applied drug. Redox-active natural compounds or structural derivatives, such as thymol (2-isopropyl-5-methylphenol), 4-isopropyl-3-methylphenol, or 3,5-dimethoxybenzaldehyde, could serve as potent chemosensitizers to enhance antifungal activity of the repurposed drug bithionol. Of note, inclusion of fungal mutants, such as antioxidant mutants, could also facilitate drug repurposing efficiency, which is reflected in the enhancement of antifungal efficacy of bithionol. Bithionol overcame antifungal (viz., fludioxonil) tolerance of the antioxidant mutants of the human/animal pathogen Aspergillus fumigatus. Altogether, our strategy can lead to the development of a high efficiency drug repurposing design, which enhances the susceptibility of pathogens to drugs, reduces time and costs for new antifungal development, and abates drug or fungicide resistance.
Article 0 Reads 3 Citations ISOLATION AND CHARACTERIZATION OF MARINE BRUCELLA FROM A SOUTHERN SEA OTTER ( ENHYDRA LUTRIS NEREIS ), CALIFORNIA, USA Melissa A. Miller, Tristan L. Burgess, Erin M. Dodd, Jack C.... Published: 01 April 2017
Journal of Wildlife Diseases, doi: 10.7589/2015-12-326
DOI See at publisher website PubMed View at PubMed
Article 0 Reads 2 Citations PREVALENCE, PATHOLOGY, AND RISK FACTORS ASSOCIATED WITH STREPTOCOCCUS PHOCAE INFECTION IN SOUTHERN SEA OTTERS ( ENHYDRA ... Georgina Bartlett, Woutrina Smith, Clare Dominik, Francesca ... Published: 01 January 2016
Journal of Wildlife Diseases, doi: 10.7589/2015-02-048
DOI See at publisher website PubMed View at PubMed
Article 0 Reads 2 Citations Pathogenesis of Streptococcus infantarius subspecies coli Isolated from Sea Otters with Infective Endocarditis Katrina L. Counihan, Verena A. Gill, Melissa A. Miller, Kath... Published: 01 June 2015
Comparative Immunology, Microbiology and Infectious Diseases, doi: 10.1016/j.cimid.2015.03.002
DOI See at publisher website PubMed View at PubMed
Article 1 Read 5 Citations Novel Bartonella infection in northern and southern sea otters (Enhydra lutris kenyoni and Enhydra lutris nereis) Sebastian E. Carrasco, Bruno B. Chomel, Verena A. Gill, Rick... Published: 01 June 2014
Veterinary Microbiology, doi: 10.1016/j.vetmic.2014.02.021
DOI See at publisher website PubMed View at PubMed
Article 1 Read 3 Citations Gangrenous mastitis caused by Bacillus species in six goats Vengai Mavangira, John A. Angelos, Eileen M. Samitz, Joan D.... Published: 15 March 2013
Journal of the American Veterinary Medical Association, doi: 10.2460/javma.242.6.836
DOI See at publisher website PubMed View at PubMed
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