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Solène Savrimoutou  - - - 
Top co-authors See all
Sylvain Routier

111 shared publications

A ICOA, UMR CNRS 7311 , University of Orleans , Orleans , France

Filomena Rossi

46 shared publications

Department of Pharmacy and CIRPeB, Università Federico II, 80134 Naples, Italy;(D.T.);(A.A.);(C.D.);(V.M.)

Mathieu Marchivie

23 shared publications

Univ. Bordeaux, ICMCB CNRS-UPR 9048, Pessac Cedex, France

Stéphane Moreau

20 shared publications

Univ. Bordeaux, UFR des Sciences Pharmaceutiques, INSERM U1212 / CNRS UMR 5320, Laboratoire ARNA, Bordeaux Cedex, France

Vanessa Desplat

18 shared publications

Cellules souches hématopoïétiques normales et leucémiques, INSERM U1035, UFR des Sciences Pharmaceutiques, Univ. Bordeaux, CEDEX, F-33076 Bordeaux, France

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Article 2 Reads 0 Citations Crystal structure and identification of a pyrimido[6,1-b][1,3]oxazin-6-one derivative from the reaction of acrolein with... Jean Guillon, Sandra Rubio, Solène Savrimoutou, François Hal... Published: 01 November 2018
Comptes Rendus Chimie, doi: 10.1016/j.crci.2018.09.013
DOI See at publisher website ABS Show/hide abstract
The X-ray crystal structure of 2-(4,5-dihydro-5-phenoxymethyl-1,3-oxazol-2-ylamino)-7-(2-hydroxy-3-phenoxypropyl)hexahydro-2H,6H-pyrimido[6,1-b][1,3]oxazin-6-one (1), a structure of adduct formed by the reaction of 5-(phenoxymethyl)-2-amino-2-oxazoline and acrolein, has been established. The present work deals with the structural identification of the adduct 1 and presents a plausible mechanism for its formation. It crystallizes in the monoclinic space group P21/c with cell parameters a = 21.3337 (10) Å, b = 11.3712 (7) Å, c = 10.4936 (7) Å, β = 103.041 (3), V = 2480.0 (3) Å3, Z = 4. C26H32N4O6, Dc = 1.330 g/cm3, μ (Cu Kα) = 1.5418 Å, S = 1.188, F (000) = 1056, R = 0.0501, and wR = 0.1584. La structure complète de la 2-(4,5-dihydro-5-phénoxymethyl-1,3-oxazol-2-ylamino)-7-(2-hydroxy-3-phénoxypropyl)hexahydro-2H,6H-pyrimido[6,1-b][1,3]oxazin-6-one 1, une structure d'adduit formée lors de la réaction de la 5-(phénoxyméthyl)-2-amino-2-oxazoline et de l'acroléine, a été établie sans équivoque par une analyse cristallographique aux rayons X. Le présent travail porte sur l'identification structurale de l'adduit 1 et présente un mécanisme plausible pour sa formation. La molécule cristallise dans le système monoclinique, dans le groupe spatial P21/c avec a = 21.3337 (10) Å, b = 11.3712 (7) Å, c = 10.4936 (7) Å, β = 103.041 (3), V = 2480.0 (3) Å3, Z = 4. C26H32N4O6, Dc = 1.330 g/cm3, μ (Cu Kα) = 1.5418 Å, S = 1.188, F (000) = 1056, R = 0.0501 et wR = 0.1584.
Article 4 Reads 0 Citations 1-Methyl-3-{4-[(4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl)benzyl]}-2-phenylindole Jean Guillon, Solène Savrimoutou, Sandra Rubio, Vanessa Desp... Published: 04 October 2018
Molbank, doi: 10.3390/m1023
DOI See at publisher website ABS Show/hide abstract
The 1-methyl-3-{4-[(4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl)benzyl]}-2-phenylindole compound has been successfully synthesized via a multistep pathway starting from 2-phenylindole. Structure characterization of this new indole derivative was done by FTIR, 1H-NMR, 13C-NMR, and HRMS spectral analysis. The title compound showed high cytotoxic potential against five leukemia cell lines (K562, HL60, U937, U266, and Jurkat cell lines).
Article 0 Reads 3 Citations Synthesis and Antiproliferative Effect of Ethyl 4-[4-(4-Substituted Piperidin-1-yl)]benzylpyrrolo[1,2-a ]quinoxalinecarb... Vanessa Desplat, Marian Vincenzi, Romain Lucas, Stéphane Mor... Published: 05 April 2017
ChemMedChem, doi: 10.1002/cmdc.201700049
DOI See at publisher website PubMed View at PubMed
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