Please login first
Monica Demurtas  - - - 
Top co-authors
Jan Balzarini

70 shared publications

KU Leuven—University of Leuven, Department of Microbiology and Immunology, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, Leuven B-3000, Belgium

Valentina Onnis

49 shared publications

Dipartimento di Scienze della Vita e dell’Ambiente, Sezione di Scienze Farmaceutiche, Farmacologiche e Nutraceutiche, Università degli Studi di Cagliari, Via Ospedale 72, Cagliari I-09124, Italy

Sandra Liekens

33 shared publications

KU Leuven—University of Leuven, Department of Microbiology and Immunology, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, Leuven B-3000, Belgium

Salvatore Pacifico

11 shared publications

Dipartmento di Scienze Chimiche e Farmaceutiche, Università degli Studi di Ferrara, Via Fossato di Mortara 17-19, Ferrara I-44121, Italy

Alessandro Deplano

10 shared publications

Department of Chemistry, American University, Washington, DC 20016, USA

1
Publication
0
Reads
0
Downloads
4
Citations
Publication Record
Distribution of Articles published per year 
(2016)
Total number of journals
published in
 
1
 
Publications
Article 3 Reads 4 Citations Design, Synthesis and Evaluation of Antiproliferative Activity of New Benzimidazolehydrazones Valentina Onnis, Monica Demurtas, Alessandro Deplano, Gianfr... Published: 30 April 2016
Molecules, doi: 10.3390/molecules21050579
DOI See at publisher website PubMed View at PubMed ABS Show/hide abstract
The synthesis and antiproliferative activity of new benzimidazole derivatives bearing an hydrazone mojety at the 2-position is described. The new N′-(4-arylidene)-1H-benzo[d]imidazole-2-carbohydrazides were evaluated for their cytostatic activity toward the murine leukemia (L1210), human T-cell leukemia (CEM), human cervix carcinoma (HeLa) and human pancreas carcinoma cells (Mia Paca-2). A preliminary structure-activity relationship could be defined. Some of the compounds possess encouraging and consistent antiproliferative activity, having IC50 values in the low micromolar range.
Top