Distribution of Articles published per year
(1989 - 2018)
(1989 - 2018)
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Article 0 Reads 0 Citations Representation of DNA environment: Spiral staircase distribution function Published: 09 October 2018
Journal of Computational Chemistry, doi: 10.1002/jcc.25549
PROCEEDINGS-ARTICLE 109 Reads 0 Citations Impact of different geometrical structures of copper(II) complexes on interactions with bio-relevant nucleophiles under ... Published: 24 August 2018
Proceedings of 4th International Electronic Conference on Medicinal Chemistry, doi: 10.3390/ecmc-4-05479
Over the past decades, transition metal complexes have attracted considerable attention in medicinal inorganic chemistry, especially as synthetic metallonucleases and metal-based anticancer drugs that are able to bind to DNA under physiological conditions (Pessoa, J.C., et al. J. Inorg. Biochem. 2011, 105, 637-644). Copper(II) complexes offer various potential advantages as antimicrobial, antiviral, anti-inflammatory, antitumor agents, enzyme inhibitors, chemical nucleases, and they are also beneficial against several diseases like copper rheumatoid and gastric ulcers (Fricker, S.P., Dalton Trans. 2007, 43, 4903-4917). Substitution reactions of square-planar [CuCl2(en)] and square-pyramidal [CuCl2(terpy)] complexes (where en= 1,2-diaminoethane and terpy= 2,2’:6’,2’’- terpyridine) with bio-relevant nucleophiles have been investigated at pH 7.4 in the presence of 0.010 M NaCl. Mechanism of substitution was probed via mole-ratio, kinetic, mass spectroscopy and EPR studies. In the presence of an excess of chloride, the octahedral complex anion [CuCl4(en)]2- forms rapidly while equilibrium reaction was observed for [CuCl2(terpy)]. Different order of reactivity of selected bio-molecules toward Cu(II) complexes was observed. The nature of the buffer just affects the Cu(II) complexes conformational dynamics. According to EPR data L-Methionine forms a most stable complex with [CuCl2(en)] among the bio-ligands considered while [CuCl2(terpy)] complex is very stable and there are no significant changes in its square-pyramidal geometry in the presence of buffers or bio-ligands. The obtained results represent progress in investigation of the mechanism of substitution reactions between Cu(II) complexes and biological relevant nuclepohiles. Also, they provide very useful information for the future design of potential copper-based anticancer drugs (Selimović, E., et al. J. Coord. Chem. 2018, 71(7), 1003-1019).
Article 9 Reads 2 Citations Substitution behavior of square-planar and square-pyramidal Cu(II) complexes with bio-relevant nucleophiles Published: 03 April 2018
Journal of Coordination Chemistry, doi: 10.1080/00958972.2018.1456656
Article 0 Reads 0 Citations Experimental strategies for 13C–15N dipolar NMR spectroscopy in liquid crystals at the natural isotopic abundance Published: 01 January 2018
Physical Chemistry Chemical Physics, doi: 10.1039/c8cp04161j
Novel routes to study molecular structure and dynamics in ordered fluids by exploiting direct dipole spin interactions between rare isotopes.
Article 4 Reads 3 Citations Theoretically possible spatial accuracy of geomagnetic maps used by migrating animals Published: 22 March 2017
Journal of The Royal Society Interface, doi: 10.1098/rsif.2016.1002
Many migrating animals, belonging to different taxa, annually move across the globe and cover hundreds and thousands of kilometres. Many of them are able to show site fidelity, i.e. to return to relatively small migratory targets, from distant areas located beyond the possible range of direct sensory perception. One widely debated possibility of how they do it is the use of a magnetic map, based on the dependence of parameters of the geomagnetic field (total field intensity and inclination) on geographical coordinates. We analysed temporal fluctuations of the geomagnetic field intensity as recorded by three geomagnetic observatories located in Europe within the route of many avian migrants, to study the highest theoretically possible spatial resolution of the putative map. If migratory birds measure total field intensity perfectly and take the time of day into account, in northern Europe 81% of them may return to a strip of land of 43 km in width along one of coordinates, whereas in more southern areas such a strip may be narrower than 10 km. However, if measurements are performed with an error of 0.1%, the strip width is increased by approximately 40 km, so that in spring migrating birds are able to return to within 90 km of their intended goal. In this case, migrating birds would probably need another navigation system, e.g. an olfactory map, intermediate between the large-scale geomagnetic map and the local landscape cues, to locate their goal to within several kilometres.
PROCEEDINGS-ARTICLE 0 Reads 0 Citations Reconstruction of realistic three-dimensional models of biological objects from MR-images for the radiation therapy purp... Published: 01 January 2017
Information Technology and Nanotechnology 2017, doi: 10.18287/1613-0073-2017-1904-293-295