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Kirkwood M. Land  - - - 
Top co-authors See all
Mendel Friedman

348 shared publications

Healthy Processed Foods Research, Western Regional Research Center, Agricultural Research Service, United States Dept. of Agriculture, Albany, CA, 94710, U.S.A.

Peter J. Sadler

211 shared publications

Department of Chemistry; University of Warwick; Coventry CV4 7AL UK

Vicky M. Avery

188 shared publications

Eskitis Institute for Drug DiscoveryGriffith University Brisbane Innovation Park Campus Nathan QLD 4111 Australia

Vipan Kumar

127 shared publications

A Department of Chemistry , Guru Nanak Dev University , Amritsar , India

Lisa A. Tell

106 shared publications

Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California at Davis, One Shields Avenue, Davis, CA 95616, USA

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Distribution of Articles published per year 
(2010 - 2019)
Total number of journals
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20
 
Publications See all
Article 0 Reads 0 Citations High Efficiency Drug Repurposing Design for New Antifungal Agents Jong H. Kim, Kathleen L. Chan, Luisa W. Cheng, Lisa A. Tell,... Published: 17 April 2019
Methods and Protocols, doi: 10.3390/mps2020031
DOI See at publisher website ABS Show/hide abstract
Current antifungal interventions have often limited efficiency in treating fungal pathogens, particularly those resistant to commercial drugs or fungicides. Antifungal drug repurposing is an alternative intervention strategy, whereby new utility of various marketed, non-antifungal drugs could be repositioned as novel antifungal agents. In this study, we investigated “chemosensitization” as a method to improve the efficiency of antifungal drug repurposing, wherein combined application of a second compound (viz., chemosensitizer) with a conventional, non-antifungal drug could greatly enhance the antifungal activity of the co-applied drug. Redox-active natural compounds or structural derivatives, such as thymol (2-isopropyl-5-methylphenol), 4-isopropyl-3-methylphenol, or 3,5-dimethoxybenzaldehyde, could serve as potent chemosensitizers to enhance antifungal activity of the repurposed drug bithionol. Of note, inclusion of fungal mutants, such as antioxidant mutants, could also facilitate drug repurposing efficiency, which is reflected in the enhancement of antifungal efficacy of bithionol. Bithionol overcame antifungal (viz., fludioxonil) tolerance of the antioxidant mutants of the human/animal pathogen Aspergillus fumigatus. Altogether, our strategy can lead to the development of a high efficiency drug repurposing design, which enhances the susceptibility of pathogens to drugs, reduces time and costs for new antifungal development, and abates drug or fungicide resistance.
Article 1 Read 0 Citations Cinnamoyl-Oxaborole Amides: Synthesis and Their in Vitro Biological Activity Maureen Gumbo, Richard M. Beteck, Tawanda Mandizvo, Ronnett ... Published: 15 August 2018
Molecules, doi: 10.3390/molecules23082038
DOI See at publisher website PubMed View at PubMed ABS Show/hide abstract
Due to the increased interest in their application in the treatment of infectious diseases, boron-containing compounds have received a significant coverage in the literature. Herein, a small set of novel cinnamoly-oxaborole amides were synthesized and screened against nagana Trypanosoma brucei brucei for antitrypanosomal activity. Compound 5g emerged as a new hit with an in vitro IC50 value of 0.086 μM against T. b. brucei without obvious inhibitory activity against HeLa cell lines. The same series was also screened against other human pathogens, including Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), for which moderate to weak activity (10 to >125 μM) was observed. Similarly, these compounds exhibited moderate activity against the human protozoal pathogen Trichomonas vaginalis with no observed effect on common microbiome bacterial species. The cross-species inhibitory activity presents the possibility of these compounds serving as broad-spectrum antibiotics for these prevalent three human pathogens.
Article 0 Reads 1 Citation Potato Peels and Their Bioactive Glycoalkaloids and Phenolic Compounds Inhibit the Growth of Pathogenic Trichomonads Mendel Friedman, Vincent Huang, Quincel Quiambao, Sabrina No... Published: 24 July 2018
Journal of Agricultural and Food Chemistry, doi: 10.1021/acs.jafc.8b01726
DOI See at publisher website
Article 0 Reads 0 Citations Frontispiece: Organometallic Conjugates of the Drug Sulfadoxine for Combatting Antimicrobial Resistance Prinessa Chellan, Vicky M. Avery, Sandra Duffy, James A. Tri... Published: 17 July 2018
Chemistry – A European Journal, doi: 10.1002/chem.201884064
DOI See at publisher website
Article 0 Reads 0 Citations Organometallic Conjugates of the Drug Sulfadoxine for Combatting Antimicrobial Resistance Prinessa Chellan, Vicky M. Avery, Sandra Duffy, James A. Tri... Published: 13 June 2018
Chemistry – A European Journal, doi: 10.1002/chem.201801090
DOI See at publisher website
Article 0 Reads 2 Citations Phytochemical-rich foods inhibit the growth of pathogenic trichomonads Sabrina M. Noritake, Jenny Liu, Sierra Kanetake, Carol E. Le... Published: 13 September 2017
BMC Complementary and Alternative Medicine, doi: 10.1186/s12906-017-1967-x
DOI See at publisher website PubMed View at PubMed ABS Show/hide abstract
Plants produce secondary metabolites that often possess widespread bioactivity, and are then known as phytochemicals. We previously determined that several phytochemical-rich food-derived preparations were active against pathogenic foodborne bacteria. Trichomonads produce disease (trichomoniasis) in humans and in certain animals. Trichomonads are increasingly becoming resistant to conventional modes of treatment. It is of interest to test bioactive, natural compounds for efficacy against these pathogens. Using a cell assay, black tea, green tea, grape, pomegranate, and jujube extracts, as well as whole dried jujube were tested against three trichomonads: Trichomonas vaginalis strain G3 (found in humans), Tritrichomonas foetus strain D1 (found in cattle), and Tritrichomonas foetus-like organism strain C1 (found in cats). The most effective of the test substances was subsequently tested against two metronidazole-resistant Trichomonas vaginalis strains, and on normal mucosal flora. Black tea extract inhibited all the tested trichomonads, but was most effective against the T. vaginalis organisms. Inhibition by black tea was correlated with the total and individual theaflavin content of the two tea extracts determined by HPLC. Metronidazole-resistant Trichomonas vaginalis strains were also inhibited by the black tea extract. The response of the organisms to the remaining preparations was variable and unique. We observed no effect of the black tea extract on common normal flora bacteria. The results suggest that the black tea, and to a lesser degree green tea, grape seed, and pomegranate extracts might present possible natural alternative therapeutic agents to treat Trichomonas vaginalis infections in humans and the related trichomonad infections in animals, without negatively affecting the normal flora.
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