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Kirkwood M. Land  - - - 
Top co-authors See all
Mendel Friedman

216 shared publications

Western Regional Research Center, Agricultural Research Service, U.S. Department of Agriculture, Albany, CA 94710, USA

Vicky Avery

151 shared publications

Discovery Biology, Griffith Institute for Drug Discovery, Griffith University, Nathan, Queensland, 4111, Australia

Peter J. Sadler

134 shared publications

Department of Chemistry

Sandra Duffy

62 shared publications

Discovery Biology, Griffith Institute for Drug Discovery; Griffith University; Nathan Queensland 4111 Australia

Luisa W. Cheng

55 shared publications

Foodborne Toxin Detection and Prevention Research Unit, Western Regional Research Center, Agricultural Research Services, United States Department of Agriculture, 800 Buchanan Street, Albany, CA 94710, USA

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Publication Record
Distribution of Articles published per year 
(2010 - 2018)
Total number of journals
published in
 
21
 
Publications See all
Article 0 Reads 0 Citations Highly Potent 1H-1,2,3-Triazole-Tethered Isatin-Metronidazole Conjugates Against Anaerobic Foodborne, Waterborne, and Se... Sumit Kumar, Trpta Bains, Ashley Sae Won Kim, Christina Tam,... Published: 30 October 2018
Frontiers in Microbiology, doi: 10.3389/fcimb.2018.00380
DOI See at publisher website ABS Show/hide abstract
Parasitic infections like amebiasis, trichomoniasis, and giardiasis are major health threats in tropical and subtropical regions of the world. Metronidazole (MTZ) is the current drug of choice for amebiasis, giardiasis, and trichomoniasis but it has several adverse effects and potential resistance is a concern. In order to develop alternative antimicrobials, a library of 1H-1,2,3-triazole-tethered metronidazole-isatin conjugates was synthesized using Huisgen's azide-alkyne cycloaddition reaction and evaluated for their amebicidal, anti-trichomonal, and anti-giardial potential. Most of the synthesized conjugates exhibited activities against Trichomonas vaginalis, Tritrichomonas foetus, Entamoeba histolytica, and Giardia lamblia. While activities against T. vaginalis and T. foetus were comparable to that of the standard drug MTZ, better activities were observed against E. histolytica and G. lamblia. Conjugates 9d and 10a were found to be 2–3-folds more potent than MTZ against E. histolytica and 8–16-folds more potent than MTZ against G. lamblia. Further analysis of these compounds on fungi and bacteria did not show inhibitory activity, demonstrating their specific anti-protozoal properties.
Article 0 Reads 0 Citations Cinnamoyl-Oxaborole Amides: Synthesis and Their in Vitro Biological Activity Maureen Gumbo, Richard M. Beteck, Tawanda Mandizvo, Ronnett ... Published: 15 August 2018
Molecules, doi: 10.3390/molecules23082038
DOI See at publisher website ABS Show/hide abstract
Due to the increased interest in their application in the treatment of infectious diseases, boron-containing compounds have received a significant coverage in the literature. Herein, a small set of novel cinnamoly-oxaborole amides were synthesized and screened against nagana Trypanosoma brucei brucei for antitrypanosomal activity. Compound 5g emerged as a new hit with an in vitro IC50 value of 0.086 μM against T. b. brucei without obvious inhibitory activity against HeLa cell lines. The same series was also screened against other human pathogens, including Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), for which moderate to weak activity (10 to >125 μM) was observed. Similarly, these compounds exhibited moderate activity against the human protozoal pathogen Trichomonas vaginalis with no observed effect on common microbiome bacterial species. The cross-species inhibitory activity presents the possibility of these compounds serving as broad-spectrum antibiotics for these prevalent three human pathogens.
Article 0 Reads 0 Citations Potato Peels and Their Bioactive Glycoalkaloids and Phenolic Compounds Inhibit the Growth of Pathogenic Trichomonads Mendel Friedman, Vincent Huang, Quincel Quiambao, Sabrina No... Published: 24 July 2018
Journal of Agricultural and Food Chemistry, doi: 10.1021/acs.jafc.8b01726
DOI See at publisher website
Article 0 Reads 0 Citations Frontispiece: Organometallic Conjugates of the Drug Sulfadoxine for Combatting Antimicrobial Resistance Prinessa Chellan, Vicky M. Avery, Sandra Duffy, James A. Tri... Published: 17 July 2018
Chemistry - A European Journal, doi: 10.1002/chem.201884064
DOI See at publisher website
Article 0 Reads 0 Citations Organometallic Conjugates of the Drug Sulfadoxine for Combatting Antimicrobial Resistance Prinessa Chellan, Vicky M. Avery, Sandra Duffy, James A. Tri... Published: 13 June 2018
Chemistry - A European Journal, doi: 10.1002/chem.201801090
DOI See at publisher website
Article 0 Reads 0 Citations Synthesis and Preliminary Antimicrobial Analysis of Isatin–Ferrocene and Isatin–Ferrocenyl Chalcone Conjugates Amandeep Singh, Grant Fong, Jenny Liu, Yun-Hsuan Wu, Kevin C... Published: 30 May 2018
ACS Omega, doi: 10.1021/acsomega.8b00553
DOI See at publisher website
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